News

We are hiring a lab technician

Abcell-bio is searching for a talented and dedicated lab technician who would become part of our developing production unit. The candidates will be responsible for isolating our main product, hematopoietic stem cells. Responsibilities: Isolate primary cells proposed by Abcell-bio, especially CD34+ hematopoietic stem cells from cord blood under controlled atmosphere. Follow Standard Operating Procedures (SOPs) to ensure product specifications are met. Ensure that quality controls and traceability of the produced batches are in accordance with Abcell-bio standards. Participate in the daily laboratory life. Respect the health and safety rules of the laboratory. Qualifications: Training : HND / Professional bachelor’s degree in biotechnology (bac + 2/3). You have knowledge in the field of mammalian cell culture (preferably extensive experience from working in a L2 environment). You have worked with mammalian cell analysis and characterization techniques such as flow cytometry and IHC, would be an asset. Given the international environment of the company, a

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Abcell-bio offers an M2 internship position

Abcell-bio offers an M2 internship position for its R&D project on isolated CD34+ cells from cord blood. Duties: The goal is to optimize and develop new products that would meet the needs of research laboratories. The student will be supervised by the scientific project manager and will work with the laboratory team. He/she will be involved in the design of experiments and will perform the experiments (cell culture, flow cytometry,…). He/she will also analyze the data and be part of discussions around the project. The student will have to follow standard operating procedures according to our quality management system.  Location: Evry (91000), France Educational level: M2 degree (ongoing) with minimum 12/20 in M1.  Applications to be sent to jobs@abcell-bio.com

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Humanized mice using CD34+ from cord blood for investigating malaria parasite

This article describe a new humanized mice model that is a unique tool for investigating, in vivo, the biology of Plasmodium vivax, the most widespread human malaria parasite. This new model of humanized mice using CD34+ cells from cord blood (purchased from Abcell-bio company), allows a reconstitution of the human erythropoiesis.  Conclusion : This model holds promise for understanding in vivo host-parasite interactions and could offer a unique opportunity for in vivo testing of novel antimalarial interventions. Luiza-Batista C, et al. Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission. Nat Commun. 2022 Jul 15;13(1):4123. doi: 10.1038/s41467-022-31864-6. 

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Ex vivo expansion of hematopoietic progenitors: interest of a new bioactive peptide.

Although umbilical cord blood (UCB) is a promising source of Hematopoietic stem and progenitor cells (HSPCs), the low dose of HSPCs in these preparations limits their use, prompting need for ex vivo HSPC expansion. This study reports the development of a bioactive peptide named SL-13R, the design of which was originally derived from sequence of the extracellular domain of Delta-like homologue 1 (DLK1) protein, expressed on hepatoblasts. UCB HSPCs were cultured with SL-13R in combination with hematopoietic cytokines under xeno-free conditions. SL-13R enhanced ex vivo expansion of UCB HSPCs without loss of long-term reconstitution ability. Transplantation of cells cultured with SL-13R into immunodeficient NOD/Shi-scid/IL-2R knockout mice confirmed that they possess long-term reconstitution and self-renewal abilities. As the specialist in the production of hematopoietic progenitors, Abcell-bio is able to provide large quantities of CD34+ cells from a single healthy donor, certifying their purity and viability. Nii T, Konno K, Matsumoto M, Bhukhai K, Borwornpinyo S, Sakai

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Risks associated with COVID-19 in pregnancy.

This article describe a new humanized mice model that is a unique tool for investigating, in vivo, the biology of Plasmodium vivax, the most widespread human malaria parasite. This new model of humanized mice using CD34+ cells from cord blood (purchased from Abcell-bio company), allows a reconstitution of the human erythropoiesis.  Conclusion : This model holds promise for understanding in vivo host-parasite interactions and could offer a unique opportunity for in vivo testing of novel antimalarial interventions. Luiza-Batista C, et al. Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission. Nat Commun. 2022 Jul 15;13(1):4123. doi: 10.1038/s41467-022-31864-6. 

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Human Umbilical Vein Endothelial Cell Support Bone Formation of Adipose-Derived Stem Cell

This study aims at investigating the co-implantation of human adipose-derived stem cells (ADSCs) after osteogenic differentiation and human umbilical vein endothelial cells (HUVECs) embedded in a vascularized osteogenic matrix of hydroxyapatite (HAp) ceramic for bone tissue engineering. Interestingly, the implantation of HUVEC led to bone formation, suggesting that implanted HUVEC stimulated bone formation. This result may be caused the ability of the extracellular matrix from HUVEC to stimulate the osteogenic differentiation of osteoprogenitor cells. The implantation of osteogenically differentiated ADSC led to higher bone formation than the implantation of HUVEC. But only the co-implantation of ADSC and HUVEC led to a statistically significant larger bone area compared to the other cell-containing groups. This supports the results of earlier studies which showed that endothelial cells stimulate proliferation, cell survival and osteogenic differentiation of osteoprogenitor cells in vitro and bone formation in vivo. Hence, the co-implantation of differentiated ADSCs with HUVECs may therefore be considered

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Abcell-bio is now part of the France Biotech network!

Biotechnology laboratory, Abcell-bio produces quality primary human cells from perinatal tissues. Our team is made up of dedicated scientists, whose objective is to facilitate the R&D work of our customers by forging real partnerships. As such, Abcell-bio is now part of the France Biotech network, whose role is to federate HealthTechs and MedTechs companies in France. The objective is to develop partnerships, private or public, in order to be more and more a player in the ecosystem of health innovation! Would you like to develop a research partnership? Contact us, the scientific team will be delighted to answer your questions and support you in your projects.

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Which are the factors affecting human umbilical cord blood quality before cryopreservation?

Umbilical cord blood (UCB) is a rich source of hematopoietic stem cells (HSCs). Comparatively, UCB HSCs have an extensive proliferative capacity that exceeds that of bone marrow HSCs. However, the small quantity of HSCs obtained from an umbilical cord remains a problematic element restricting the usage of UCB and the quality of UCB units has to be checked before cryopreservation. This study aimed to determine the maternal and neonatal factors that influence UCB before selection for cryopreservation. The analysis included 403 processed UCB units. Neonates with higher birth weights produced better quality UCB units because of increased collected blood volumes, total nucleated cell counts, and CD34+ cell counts. However, an increase in the gestational age from 35 to 41 weeks led to decreases in the collected blood volume and CD34+ cell count. As the specialist in the production of CD34+ progenitors from cord blood, Abcell-bio controls the collection and the selection

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Abcell-bio has obtained French Research Tax Credit (CIR) agreement

For several years, Abcell-bio has been committed to its customers in order to facilitate their Research and Development projects. To go further, Abcell-bio has obtained the CIR agreement, which allows French companies to benefit from a tax credit on the expenses engaged in Research & Development or experimental procedures. It has been delivered by the French Ministry of Higher Education, Research & Innovation and it is valid for 3 years, until 2022. The basis for eligibility is an investment in research and development within the European Economic Area. Please do not hesitate to contact us for any question, our scientific team is at your disposal.

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Human CD34 + Hematopoietic Stem Cell-Engrafted NSG Mice: Morphological and Immunophenotypic Features

This study at characterizing the morphological phenotype of NSG mice and their humanized counterparts.  CD34+ hu-NSG murine model was generated via perinatal intrahepatic injection of human CD34+ fetal liver cells into NSG mice after preconditioning irradiation. Another purpose of this study was to assess the spectrum of histopathological lesions and identify the main causes of morbidity and mortality in young NSG mice and CD34+ HSC hu-NSG mice. Indeed, despite the increased popularity of these animal models in preclinical research, data on this topic are very sparse. The study describes the most common pathological features in young NSG mice after human hematopoietic stem cell engraftment. Mice frequently showed nephropathy, ovarian atrophy, cataract, and abnormal retinal development, lesions considered secondary to irradiation. In addition, 20% exhibited multisystemic granulomatous inflammatory infiltrates, dominated by human macrophages and T cells, leading to the observed 7% of mortality and morbidity. As some of these lesions contribute

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