News

Abcell-bio Secures CIR Agreement from French Ministry: Offering Enhanced Access to Cord Blood Cells and Tax Benefits for R&D Partners

Abcell-bio arose from the will to accompany research by facilitating the access to primary resources which are difficult to get, especially cells from cord blood. With a strong and unique network of French maternities and a robust production process, Abcell-bio also develops a Research & Development activity to face the challenges of the upcoming research. To that extent, Abcell-bio has obtained the CIR agreement (Crédit d’Impôt Recherche; Research Tax Credit) from the French Ministry of Education, Research and Innovation for 2023, 2024 and 2025. Thanks to this agreement, our French partners can benefit from a tax refund on contractual services used for Research and Development activities. Contact us for more information, our scientific team is available to help you with your projects.

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Did you say Red September?

Every year, we hear about Pink October and Movember, but Red September isn’t as widely recognized. This month is dedicated to raising awareness for blood cancers, which affect 45,000 individuals annually in France. ‘Live with a MPN’, a patient association, launched this initiative last year and is now rolling out its second edition. Abcell-bio supports research and provides French labs with access to reliable sources of hematopoietic cells, propelling advancements in the field of onco-hematology. Let’s come together to raise awareness for #RedSeptember and #bloodcancers. ‘Red September – it’s about me, it’s about you, it’s about all of us. Blood cancers don’t just affect others!’ For more details, please visit: https://lnkd.in/d3bvkDqc.”

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We are hiring a lab technician

Abcell-bio is searching for a talented and dedicated lab technician who would become part of our developing production unit. The candidates will be responsible for isolating our main product, hematopoietic stem cells. Responsibilities: Isolate primary cells proposed by Abcell-bio, especially CD34+ hematopoietic stem cells from cord blood under controlled atmosphere. Follow Standard Operating Procedures (SOPs) to ensure product specifications are met. Ensure that quality controls and traceability of the produced batches are in accordance with Abcell-bio standards. Participate in the daily laboratory life. Respect the health and safety rules of the laboratory. Qualifications: Training : HND / Professional bachelor’s degree in biotechnology (bac + 2/3). You have knowledge in the field of mammalian cell culture (preferably extensive experience from working in a L2 environment). You have worked with mammalian cell analysis and characterization techniques such as flow cytometry and IHC, would be an asset. Given the international environment of the company, a

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Abcell-bio offers an M2 internship position

Abcell-bio offers an M2 internship position for its R&D project on isolated CD34+ cells from cord blood. Duties: The goal is to optimize and develop new products that would meet the needs of research laboratories. The student will be supervised by the scientific project manager and will work with the laboratory team. He/she will be involved in the design of experiments and will perform the experiments (cell culture, flow cytometry,…). He/she will also analyze the data and be part of discussions around the project. The student will have to follow standard operating procedures according to our quality management system.  Location: Evry (91000), France Educational level: M2 degree (ongoing) with minimum 12/20 in M1.  Applications to be sent to jobs@abcell-bio.com

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Humanized mice using CD34+ from cord blood for investigating malaria parasite

This article describe a new humanized mice model that is a unique tool for investigating, in vivo, the biology of Plasmodium vivax, the most widespread human malaria parasite. This new model of humanized mice using CD34+ cells from cord blood (purchased from Abcell-bio company), allows a reconstitution of the human erythropoiesis.  Conclusion : This model holds promise for understanding in vivo host-parasite interactions and could offer a unique opportunity for in vivo testing of novel antimalarial interventions. Luiza-Batista C, et al. Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission. Nat Commun. 2022 Jul 15;13(1):4123. doi: 10.1038/s41467-022-31864-6. 

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Ex vivo expansion of hematopoietic progenitors: interest of a new bioactive peptide.

Although umbilical cord blood (UCB) is a promising source of Hematopoietic stem and progenitor cells (HSPCs), the low dose of HSPCs in these preparations limits their use, prompting need for ex vivo HSPC expansion. This study reports the development of a bioactive peptide named SL-13R, the design of which was originally derived from sequence of the extracellular domain of Delta-like homologue 1 (DLK1) protein, expressed on hepatoblasts. UCB HSPCs were cultured with SL-13R in combination with hematopoietic cytokines under xeno-free conditions. SL-13R enhanced ex vivo expansion of UCB HSPCs without loss of long-term reconstitution ability. Transplantation of cells cultured with SL-13R into immunodeficient NOD/Shi-scid/IL-2R knockout mice confirmed that they possess long-term reconstitution and self-renewal abilities. As the specialist in the production of hematopoietic progenitors, Abcell-bio is able to provide large quantities of CD34+ cells from a single healthy donor, certifying their purity and viability. Nii T, Konno K, Matsumoto M, Bhukhai K, Borwornpinyo S, Sakai

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Risks associated with COVID-19 in pregnancy.

This article describe a new humanized mice model that is a unique tool for investigating, in vivo, the biology of Plasmodium vivax, the most widespread human malaria parasite. This new model of humanized mice using CD34+ cells from cord blood (purchased from Abcell-bio company), allows a reconstitution of the human erythropoiesis.  Conclusion : This model holds promise for understanding in vivo host-parasite interactions and could offer a unique opportunity for in vivo testing of novel antimalarial interventions. Luiza-Batista C, et al. Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission. Nat Commun. 2022 Jul 15;13(1):4123. doi: 10.1038/s41467-022-31864-6. 

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Human Umbilical Vein Endothelial Cell Support Bone Formation of Adipose-Derived Stem Cell

This study aims at investigating the co-implantation of human adipose-derived stem cells (ADSCs) after osteogenic differentiation and human umbilical vein endothelial cells (HUVECs) embedded in a vascularized osteogenic matrix of hydroxyapatite (HAp) ceramic for bone tissue engineering. Interestingly, the implantation of HUVEC led to bone formation, suggesting that implanted HUVEC stimulated bone formation. This result may be caused the ability of the extracellular matrix from HUVEC to stimulate the osteogenic differentiation of osteoprogenitor cells. The implantation of osteogenically differentiated ADSC led to higher bone formation than the implantation of HUVEC. But only the co-implantation of ADSC and HUVEC led to a statistically significant larger bone area compared to the other cell-containing groups. This supports the results of earlier studies which showed that endothelial cells stimulate proliferation, cell survival and osteogenic differentiation of osteoprogenitor cells in vitro and bone formation in vivo. Hence, the co-implantation of differentiated ADSCs with HUVECs may therefore be considered

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Abcell-bio is now part of the France Biotech network!

Biotechnology laboratory, Abcell-bio produces quality primary human cells from perinatal tissues. Our team is made up of dedicated scientists, whose objective is to facilitate the R&D work of our customers by forging real partnerships. As such, Abcell-bio is now part of the France Biotech network, whose role is to federate HealthTechs and MedTechs companies in France. The objective is to develop partnerships, private or public, in order to be more and more a player in the ecosystem of health innovation! Would you like to develop a research partnership? Contact us, the scientific team will be delighted to answer your questions and support you in your projects.

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Which are the factors affecting human umbilical cord blood quality before cryopreservation?

Umbilical cord blood (UCB) is a rich source of hematopoietic stem cells (HSCs). Comparatively, UCB HSCs have an extensive proliferative capacity that exceeds that of bone marrow HSCs. However, the small quantity of HSCs obtained from an umbilical cord remains a problematic element restricting the usage of UCB and the quality of UCB units has to be checked before cryopreservation. This study aimed to determine the maternal and neonatal factors that influence UCB before selection for cryopreservation. The analysis included 403 processed UCB units. Neonates with higher birth weights produced better quality UCB units because of increased collected blood volumes, total nucleated cell counts, and CD34+ cell counts. However, an increase in the gestational age from 35 to 41 weeks led to decreases in the collected blood volume and CD34+ cell count. As the specialist in the production of CD34+ progenitors from cord blood, Abcell-bio controls the collection and the selection

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