This article describe a new humanized mice model that is a unique tool for investigating, in vivo, the biology of Plasmodium vivax, the most widespread human malaria parasite. This new model of humanized mice using CD34+ cells from cord blood (purchased from Abcell-bio company), allows a reconstitution of the human erythropoiesis.
Conclusion : This model holds promise for understanding in vivo host-parasite interactions and could offer a unique opportunity for in vivo testing of novel antimalarial interventions.
Luiza-Batista C, et al. Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission. Nat Commun. 2022 Jul 15;13(1):4123. doi: 10.1038/s41467-022-31864-6.